Réfénasin
Rincian produk
Tag produk
| Ukuran Pek | Kasadiaan | Harga (USD) |
| 10 mg | Aya sasayogian | 200 |
| 100 mg | Aya sasayogian | 800 |
| 1g | Aya sasayogian | 3400 |
| Langkung Ukuran | Meunang Tanda kutip | Meunang Tanda kutip |
Ngaran Kimia:
1-(2-(3-((4-carbamoylpiperidin-1-yl)metil)-N-methylbenzamido)étil)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate
Kode SMILES:
O=C(OC1CCN(CCN(C)C(C2=CC=C(CN3CCC(C(N)=O)CC3)C=C2)=O)CC1)NC4=CC=CC=C4C5=CC=CC= C5
Kodeu InChi:
InChI=1S/C35H43N5O4/c1-38(34(42)29-13-11-26(12-14-29)25-40-19-15-28(16-20-40)33(36)41) 23-24-39-21-17- 30(18-22-39)44-35(43)37-32-10-6-5-9-31(32)27-7-3-2-4-8-27/h2-14,28, 30H,15-25H2,1H3,(H2,36,41)(H,37,43)
Konci InChi:
FYDWDCIFZSGNBU-UHFFFAOYSA-N
kecap konci:
Revefenacin, TD-4208, GSK-1160724, TD4208, TD 4208, GSK1160724, GSK 1160724, 864750-70-9
Kalarutan:Leyur dina DMSO
Panyimpenan:0 - 4°C kanggo jangka pondok (poé ka minggu), atanapi -20°C kanggo jangka panjang (bulan).
Katerangan:
In Vitro: The Kis of revefenacin nyaéta 0.42, 0.32, 0.18, 0.56, sareng 6.7 nM dina reséptor M1, M2, M3, M4 sareng M5 manusa masing-masing. Dina uji fungsional, revefenacin ditingalikeun janten antagonis fungsional kalayan konstanta inhibisi anu sami sareng ngariung Ki. Revefenacin ogé ngahambat kontraksi agonist-ngainduksi tina guinea pig terisolasi cingcin tracheal kalawan afinitas 0,1 nM, sarupa jeung diukur M3 biding Ki[1]. Dina Vivo: Dina anjing bius, revefenacin, babarengan jeung tiotropium jeung glycopyrronium, ngahasilkeun inhibisi sustained bronchoconstriction-induced acetylcholine nepi ka 24 jam. Dina beurit anu dibius, revefenacin anu dihirup nunjukkeun bronkoproteksi 24 jam anu gumantung kana dosis ngalawan bronkokonstriksi anu diinduksi methacholine. Diperkirakeun potency 24-jam nyaéta 45.0 µg/mL jeung potency bronchoprotektif dijaga sanggeus 7 poé dosing sakali sapoé [2].
Sasaran: mAChR
