Quizartinib; AC-010220; AC-220
Rincian produk
Tag produk
| Ukuran Pek | Kasadiaan | Harga (USD) |
| 5g | Aya sasayogian | 1000 |
| 10g | Aya sasayogian | 1500 |
| Langkung Ukuran | Meunang Tanda kutip | Meunang Tanda kutip |
Ngaran Kimia:
N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yletoxy)imidazo[2,1-b][1,3]benzotiazol-2-yl ]fénil}uréa
Kode SMILES:
O=C(NC1=CC=C(C2=CN3C(SC4=CC(OCCN5CCOCC5)=CC=C34)=N2)C=C1)NC6=NOC(C(C)(C)C)=C6
Kodeu InChi:
InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22- 18-35-23-9-8-21 (16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1 -3H3,(H2,30,32,33,36)
Konci InChi:
CVWXJKQAOSCOAB-UHFFFAOYSA-N
kecap konci:
Quizartinib, AC-010220, AC010220, AC 010220, AC-220, AC220, AC 220, 950769-58-1
Kalarutan:Leyur dina DMSO
Panyimpenan:0 - 4°C kanggo jangka pondok (poé ka minggu), atanapi -20°C kanggo jangka panjang (bulan)
Katerangan:
Quizartinib mangrupikeun inhibitor tirosin kinase 3 (FLT3; Kd = 1.6 nM) anu aya hubunganana sareng FMS sareng nunjukkeun selektivitas tinggi pikeun FLT3 nalika diuji ngalawan panel 227 kinase tambahan. Éta ngahambat proliferasi garis sél leukemia manusa MV4-11, anu ngagaduhan mutasi FLT3-ITD homozigot, kalayan nilai IC50 0,56 nM.1 Dina 1 mg / kg / dinten, quizartinib parantos ditingalikeun manjangkeun kasalametan dina beurit. model FLT3-ITD leukemia myeloid akut sareng ngabasmi tumor dina beurit anu gumantung FLT3 modél xenograft dina 10 mg / kg.
Sasaran: FLT3
