AMG-510
Rincian produk
Tag produk
| Ukuran Pek | Kasadiaan | Harga (USD) |
| 1g | aya sasayogian | 1300 |
| 5g | aya sasayogian | 6000 |
| 10g | aya sasayogian | 10500 |
Ngaran Kimia:
4-((S) -4-acrylyl-2-methylpiperazin-1-yl) -6-fluoro-7-(2-fluoro-6-hydroxyphenyl) -1-(2-isopropyl-4-methylpyridin-3-yl )pyrido[2,3-d]pirimidin-2(1H)-hiji
Kode SMILES:
O=C(C=C)N1C[C@H](C)N(C2=NC(N(C3=C(C)C=CN=C3C(C)C)C4=C2C=C(F)C (C5=C(O)C=CC=C5F)=N4)=O)CC1
Kodeu InChi:
InChI=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8- 7-9-22(24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6- 11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1
Konci InChi:
NXQKSXLFSAEQCZ-SFHVURJKSA-N
kecap konci:
AMG-510; AMG 510; AMG510
Kalarutan:
Panyimpenan:
Katerangan:
AMG-510 mangrupikeun inhibitor kovalén KRAS G12C anu kuat. AMG-510 sacara selektif nargétkeun mutan KRAS p.G12C, boh dina tingkat DNA, RNA atanapi protéin, sareng nyegah, ku cara anu teu acan dijelaskeun, ekspresi sareng / atanapi sinyal sél tumor ngalangkungan mutan KRAS p.G12C. Ieu bisa ngahambat tumuwuhna sél tumor KRAS p.G12C-ekspresi
Sasaran: KRAS
