MC180295
Pikeun panalungtikan ilmiah wungkul, henteu pikeun penderita.
Rincian produk
Tag produk
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Ngaran Kimia:
Rel-(4-amino-2-(((2S)-bicyclo[2.2.1]heptan-2-yl)amino)tiazol-5-yl)(2-nitrofenil)methanone
Kode SMILES:
O=C(C1=C(N)N=C(N[C@@H]2C(C3)CCC3C2)S1)C4=CC=CC=C4[N+]([O-])=O
Kodeu InChi:
InChI=1S/C17H18N4O3S/c18-16-15(14(22)11-3-1-2-4-13(11)21(23)24)25-17(20-16)19-12-8- 9-5-6-10(12)7-9/h1-4,9-10,12H,5-8,18H2,(H,19,20)/t9?,10?,12-/m0/s1
Konci InChi:
JRNXAQINDCOHGS-CBINBANVSA-N
kecap konci:
Kalarutan:
Panyimpenan:
Katerangan:
MC180295 mangrupakeun inhibitor CDK9 kacida selektif (IC50 = 5 nM). (MC180295 boga aktivitas anti kanker lega in vitro tur éféktif dina model kanker in vivo. Salaku tambahan, inhibisi CDK9 sensitizes ka inhibitor papariksaan imun α-PD-1 in vivo, sahingga hiji target alus teuing pikeun terapi epigenetic kanker.
Sasaran: CDK9
