MSC2530818
Rincian produk
Tag produk
| Ukuran Pek | Kasadiaan | Harga (USD) |
| 100 mg | Aya sasayogian | 400 |
| Langkung Ukuran | Meunang Tanda kutip | Meunang Tanda kutip |
Ngaran Kimia:
[(2S)-2-(4-Chlorophenyl)pyrrolidin-1-yl]-(3-methyl-1H-pyrazolo[3,4-b]piridin-5-yl)methanone
Kode SMILES:
O=C(N1[C@H](C2=CC=C(Cl)C=C2)CCC1)C3=CN=C(NN=C4C)C4=C3
Kodeu InChi:
InChI=1S/C18H17ClN4O/c1-11-15-9-13(10-20-17(15)22-21-11)18(24)23-8-2-3-16(23)12-4- 6-14(19)7-5-12/h4-7,9-10,16H,2-3,8H2,1H3,(H,20,21,22)/t16-/m0/s1
Konci InChi:
ODRITQGYYWHQGM-INIZCTEOSA-N
kecap konci:
MSC2530818, MSC-2530818, MSC 2530818, 1883423-59-3
Kalarutan:Leyur dina DMSO
Panyimpenan:0 - 4°C kanggo jangka pondok (poé ka minggu), atanapi -20°C kanggo jangka panjang (bulan).
Katerangan:
MSC2530818 mangrupakeun Potent, Selektif, sarta Oral Bioavailable CDK8 Inhibitor kalawan CDK8 IC50 = 2,6 nM; Ramalan PK manusa: Cl ~ 0,14 L / H / Kg; t1/2 ~ 2,4 jam; F > 75%. MSC2530818 mintonkeun selektivitas kinase alus teuing, potency biokimiawi jeung sélular, stabilitas microsomal, sarta sacara oral bioavailable. MSC2530818 nunjukkeun potency sareng selektif anu cocog pikeun kamajuan kana preclinical in vivo efficacy and safety study.
Sasaran: CDK
