GSK2982772

Ingoa matū:

(S)-5-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b]-[1,4]oxazepin-3-yl)-4H-1,2, 4-triazole-3-carboxamide

Waehere SMILES:

O=C(C1=NN=C(CC2=CC=CC=C2)N1)N[C@@H]3C(N(C)C4=CC=CC=C4OC3)=O

Waehere InChi:

InChI=1S/C20H19N5O3/c1-25-15-9-5-6-10-16(15)28-12-14(20(25)27)21-19(26)18-22-17(2 3-24-18)11-13-7-3-2-4-8-13/h2-10,14H,11-12H2,1H3,(H,21,26)(H,22,23,24) /t14-/m0/s1

Kī InChi:

LYPAFUINURXJSG-AWEZNQCLSA-N

Kupumatua:

GSK-2982772, GSK 2982772, GSK2982772, 1622848-92-3

Wairewa:Wairewa i roto i te DMSO

Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama).

Whakaahuatanga:

Ko te GSK2982772 he kaiwhiwhi kaha me te whiriwhiri i te Interacting Protein 1 (RIP1) Kinase Kaitono Haumanu Motuhake mo te maimoatanga o nga mate mumura. Ko te GSK2982772, kei te wahanga 2a nga rangahau haumanu mo te psoriasis, te rumati rūmātiki, me te mate ulcerative colitis. He kaha te here a GSK2982772 ki te RIP1 me te tino motuhake o te kinase, he pai hoki tana mahi ki te aukati i te maha o nga whakautu pūkoro e whakawhirinaki ana ki te TNF. Kua puta te RIP1 hei kinase whakarunga nui kua kitea hei whakahaere i te mumura na roto i nga mahi e rua o te scaffolding me te kinase.

Whāinga: RIP1