H3B-6527

Ingoa matū:

N-(2-((6-(3-(2,6-dichloro-3,5-dimethoxyphenyl))-1-methylureido)pirimidin-4-yl)amino)-5-(4-ethylpiperazin-1-yl) phenyl)acrylamide

Waehere SMILES:

C=CC(NC1=CC(N2CCN(CC)CC2)=CC=C1NC3=NC=NC(N(C(NC4=C(Cl)C(OC)=CC(OC)=C4Cl)=O)C) =C3)=O

Waehere InChi:

InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34- 23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/ h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)

Kī InChi:

MBWRLLRCTIYXDW-UHFFFAOYSA-N

Kupumatua:

H3B-6527, H3B 6527, H3B6527, 1702259-66-2

Wairewa:Wairewa i roto i te DMSO

Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama).

Whakaahuatanga:

Ko te H3B-6527 (H3 Biomedicine) he aukati FGFR4 tino whiriwhiri me te kaha o te mahi antitumour i roto i te FGF19 kua whakanuia nga raina pūtau me nga kiore.

Whāinga: FGFR4