MEK

CAT #	Ingoa Hua	Whakaahuatanga
CPDB0157	BI-847325	Ko te BI-847325 he mea whiriwhiringa rua MEK / Aurora kinase inhibitor me nga uara IC50 o 3, 25, 15, 25, me 4 nM mo X. laevis Aurora B, Aurora A me Aurora C, me te MEK1 me te MEK2 tangata. Ka taea e ia te aukati i te tipu me te oranga o nga raina pūtau melanoma e rua mo te maimoatanga-kore me te aukati i te tarukino, te whakaheke i te whakahuatanga o MEK me Mcl-1 i te wa e whakanui ana te whakaaturanga o te Bim protein pro-apoptotic. I te 70 mg/kg, BI-847325 ka whakaawe i te apoptosis i roto i te melanoma xenografted maimoatanga-naive me te tarukino-aukati i roto i te vivo.