ABBV-744

Ingoa matū:

N-ethyl-4-(2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl)-6-methyl-7-oxo-6,7-dihydro-1H -pyrrolo [2,3-c] pyridine-2-carboxamide

Waehere SMILES:

O=C(C(N1)=CC(C(C2=CC(C(C)(O)C)=CC=C2OC3=C(C)C=C(F)C=C3C)=CN4C)=C1C4 =O)NCC

Waehere InChi:

InChI=1S/C28H30FN3O4/c1-7-30-26(33)22-13-20-21(14-32(6)27(34)24(20)31-22)19-12-17( 28(4,5)35)8-9-23(19)36-25-15(2)10-18(29)11-16(25)3/h8-14,31,35H,7H2,1- 6H3,(H,30,33)

Kī InChi:

OEDSFMUSNZDJFD-UHFFFAOYSA-N

Kupumatua:

ABBV-744, ABBV 744, ABBV744, 2138861-99-9

Wairewa:Wairewa i roto i te DMSO

Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama).

Whakaahuatanga:

Ko te ABBV-744 he aukati BET bromodomain kua whiriwhiria e te BDII e tirotirohia ana hei rongoa i te AML me te mate pukupuku prostate-atete metastic castration.

Whāinga: BET bromodomain