| CAT # | Ingoa Hua | Whakaahuatanga |
| CPD9470 | Waikawa Obeticholic | Ko te Waikawa Obeticholic (INT747; 6-ECDCA) he whakaputanga hou o te waikawa cholic e mahi ana hei agonist FXR kaha me te whiriwhiri e whakaatu ana i te mahi anticholeretic i roto i te tauira kiore in vivo o te cholestasis. Ka aukati i te mumura me te heke o nga uaua o te uaua me te heke me te whakatairanga i te rereketanga o te adipocyte me te whakahaere i te mahi o te pūtau adipose i roto i te vivo. |
| CPD100579 | fexaramine | Ko te Fexaramine he agonist o te farnesoid X receptor (FXR), he kaikawe karihi-a-waikawa-waikawa e whakahaere ana i te whakahiato-waikawa-waikawa, te whakakotahi me te kawe, tae atu ki te whakawhitinga lipid na roto i nga mahi i roto i te ate me te whekau. Ko te Fexaramine he 100-fold te hononga nui ake mo te FXR i nga pūhui taiao me te whakaahua i nga whaainga ira me te waahi here i runga i te FXR. I te wa i tukuna a waha ki nga kiore, ka puta nga mahi whiriwhiri a te fexaramine na roto i nga kaiwhakawhiwhi FXR i roto i nga whekau. |
| CPD100577 | Lithocholic-waikawa | Ko te Levallorphan, e mohiotia ana ko te levallorphan tartate (USAN), he kaiwhakatikatika opioid o te whanau morphinan i whakamahia hei analgesic opioid me te antagonist / antidote opioid. Ka mahi hei kaitukino mo te μ-opioid receptor (MOR) me te agonist o te κ-opioid receptor (KOR), ka mutu, ka aukati i nga paanga o nga kaihoko kaha ake me te nui ake o nga mahi penei i te morphine i te wa e whakaputa ana i te rongoa. . Hei agonist o te KOR, ka taea e levallorphan te whakaputa i nga tauhohenga hinengaro kino i te nui o nga pota tae atu ki te pohehe, te wehewehe, me etahi atu paanga psychotomimetic, dysphoria, te awangawanga, te whakama, te mangere, te koretake, te whakapouri, te haurangi, me nga moemoea rereke, rereke, raruraru ranei. . (Pūtake: https://en.wikipedia.org/wiki/Levallorphan). |
| CPD100575 | Turofexorate-Isopropyl | Ko te Turofexorate isopropyl, e mohiotia ana ko WAY-362450 me XL335, he tino kaha, he whiriwhiri, he agonist kaha o te waha o te kaiawhina X farnesoid (FXR) (EC(50) = 4 nM, Eff = 149%), e whakaiti ana i te mumura ate. me te fibrosis i roto i te tauira murine o te steatohepatitis kore-waipiro |
| CPD100574 | GW4064 | GW4064是一种farnesoid X receptor (FXR)激动剂，CV1细胞系中EC50为65 nM。浓度达到1 μM时，对其他核滀受他核受他核受他。 |
| CPD1549 | Tropifexor | Ko Tropifexor he pukapuka me te agonist tino kaha o FXR me te EC50 o 0.2 nM. |
