CAT # | Ingoa Hua | Whakaahuatanga |
CPD1573 | GDC-0077 | Ko te GDC-0077 he aukati PI3K e waatea ana me te mahi antineoplastic pea. |
CPD1022 | IPI-549 | Ko te IPI549 he Inhibitor PI3Kγ kaha me te whiriwhiri me te IC50 o 16 nM. |
CPDD3857 | GDC-0326 | Ko te GDC-0326 he kaitautoko kaha me te whiriwhiri i te α-Isoform o Phosphoinositide 3-Kinase (PI3Kalpha inhibitor). Ko te GDC-0326 ka eke ki te taumata teitei o te whiriwhiringa i runga i etahi atu kinase. Ko te GDC-0326 he iti te plasma CL i roto i te tangata. |
CPDB0202 | AZD8186 | Ko te AZD8186 me te aukati o te beta isoform o te phosphoinositide-3 kinase (PI3K), me te mahi antineoplastic pea. |
CPDB1536 | PQR530 | Ko te PQR530 he tino kaha rua pan-PI3K / mTORC1 / 2 aukati. |
CPDB1573 | GDC-0077 | Ko te GDC-0077 he aukati PI3K e waatea ana ma te waha me te whiriwhiri (IC50 = 0.038 + 0.003 nM) me te > 300-fold te whiriwhiri i runga i etahi atu momo tauira PI3K Class I. |