in vitro Pharmacokinetic Assays

Ko ta matou roopu rongoa rongoa he tohungatanga ki te whanaketanga o mua, te tirotiro DMPK me te rehitatanga IND. I whakatühia e mätou tëtahi tüäpapa hangarau tirotiro in vitro me in vivo hei tautoko i te kitenga me te whanaketanga o te tarukino. Ka tuku a Caerulum Pharma i nga ratonga ngawari me te whaiaro mo nga otinga DMPK pai me te utu-utu ki te ahu whakamua i to rangahau.

1.Wahanga ako

Ngota ngota iti, hua maori, polypeptides.

2.Ratonga e wātea ana

Te whakamatautau herenga pūmua plasma/tisu

Plasma ki te toto ōwehenga

Ate microsomal metabolic pūmautanga

Te pumau i roto i te waka me te plasma

Te tautuhi metabolite

CYP tauhohenga tohu tohu

Te aukati CYP

3.I te hanga

Hepatocyte Induction

Caco-2 Te uruhanga

UGT tauhohenga tohu tohu


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