Ko ta matou roopu rongoa rongoa he tohungatanga ki te whanaketanga o mua, te tirotiro DMPK me te rehitatanga IND. I whakatühia e mätou tëtahi tüäpapa hangarau tirotiro in vitro me in vivo hei tautoko i te kitenga me te whanaketanga o te tarukino. Ka tuku a Caerulum Pharma i nga ratonga ngawari me te whaiaro mo nga otinga DMPK pai me te utu-utu ki te ahu whakamua i to rangahau.
1.Wahanga ako
Ngota ngota iti, hua maori, polypeptides.
2.Ratonga e wātea ana
Te whakamatautau herenga pūmua plasma/tisu
Plasma ki te toto ōwehenga
Ate microsomal metabolic pūmautanga
Te pumau i roto i te waka me te plasma
Te tautuhi metabolite
CYP tauhohenga tohu tohu
Te aukati CYP
3.I te hanga
Hepatocyte Induction
Caco-2 Te uruhanga
UGT tauhohenga tohu tohu