FLT3

CAT #	Ingoa Hua	Whakaahuatanga
CPDB0099	Quizartinib; AC-010220; AC-220	Ko Quizartinib te aukati o te tyrosine kinase 3 e pa ana ki te FMS (FLT3; Kd = 1.6 nM) me te whakaatu i te whiriwhiringa teitei mo te FLT3 i te wa e whakamatautauhia ana ki te roopu o te 227 atu kinases. Ka whakakorehia e ia te tipu o te raina pūtau leukemia tangata MV4-11, e mau ana i te whakawhitinga FLT3-ITD homozygous, me te uara IC50 o 0.56 nM.1 I te 1 mg / kg / ra, kua whakaatuhia te quizartinib ki te whakawhānui i te oranga i roto i te kiore. tauira o te FLT3-ITD acute myeloid leukemia me te whakakore i nga pukupuku i roto i te kiore whakawhirinaki-FLT3 tauira xenograft i te 10 mg/kg.