CB-839

Ingoa matū:

2-(pyridin-2-yl)-N-(5-(4-(6-(2-(3-(trifluoromethoxy)phenyl)acetamido)pyridazin-3-yl)butyl)-1,3,4-thiadiazol -2-yl)acetamide

Waehere SMILES:

O=C(NC1=CC=C(CCCCC2=NN=C(NC(CC3=NC=CC=C3)=O)S2)N=N1)CC4=CC(OC(F)(F)F)=CC =C4

Waehere InChi:

InChI=1S/C26H24F3N7O3S/c27-26(28,29)39-20-9-5-6-17(14-20)15-22(37)31-21-12-11-18(33-34- 21)7-1-2-10-24-35-36-25(40-24)32-23(38)16-19-8-3-4-13-30-19/h3-6,8- 9,11-14H,1-2,7,10,15-16H2,(H,31,34,37)(H,32,36,38)

Kī InChi:

PRAAPINBUWJLGA-UHFFFAOYSA-N

Kupumatua:

CB-839, CB839, CB 839, 1439399-58-2

Wairewa:Wairewa i roto i te DMSO

Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama).

Whakaahuatanga:

"Ko te CB-839 an he aukati bioavailable o te glutaminase, me te mahi antineoplastic pea. I runga i te whakahaere a-waha, ko te CB-839 te whiriwhiri me te kore e taea te whakakore i te glutaminase, he enzyme mitochondrial he mea nui mo te huri i te waikawa amino glutamine ki te glutamate. Ma te aukati i te glutamine. Ko te whakamahi, ko te tipu i roto i nga pūtau e tipu tere ana ka whakawhirinaki ki te hurihanga o te glutamine o waho ki te glutamate me te glutamate metabolites ki te whakarato i te kaha me te whakaputa poraka whare mo te hanga macromolecules, e hiahiatia ana mo te tipu me te oranga.

Whainga: Glutaminase