GDC-0077
Taipitopito Hua
Tohu Hua
| Rahi o te kete | Te waatea | Utu (USD) |
| 100mg | Kei roto i nga taonga | 500 |
| 500mg | Kei roto i nga taonga | 800 |
| 1g | Kei roto i nga taonga | 1200 |
| Ētahi atu Rahi | Tikina Nga Korero | Tikina Nga Korero |
Ingoa matū:
(S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4 ]oxazepin-9-yl)amino)propanamide
Waehere SMILES:
C[C@@H](C(N)=O)NC1=CC=C(C2=NC(N3[C@H](C(F)F)COC3=O)=CN2CCO4)C4=C1
Waehere InChi:
InChI=1S/C18H19F2N5O4/c1-9(16(21)26)22-10-2-3-11-13(6-10)28-5-4-24-7-14(23-17(11) 24)2 5-12(15(19)20)8-29-18(25)27/h2-3,6-7,9,12,15,22H,4-5,8H2,1H3,(H2,21,26 )/t9-,12-/m0/s1
Kī InChi:
SGEUNORSOZVTOL-CABZTGLSA-N
Kupumatua:
GDC-0077, GDC0077, GDC 0077, 2060571-02-8
Wairewa:Wairewa i roto i te DMSO
Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama).
Whakaahuatanga:
Ko te GDC-0077 he aukati PI3K e waatea ana ma te waha me te whiriwhiri (IC50 = 0.038 + 0.003 nM) me te > 300-fold te whiriwhiri i runga i etahi atu momo tauira PI3K Class I. Ka mahi a GDC-0077 i tana mahi ma te here ki te pae here ATP o PI3K, na reira ka aukati i te phosphorylation o PIP2 ki PIP3.
Whāinga: PI3K
