| CAT # | Ingoa Hua | Whakaahuatanga |
| CPD100230 | JBJ-04-125-02 R-isomer | |
| CPD3232 | NTN21277 | Ko te NTN21277, e mohiotia ana ko te PROTAC 3-a-Gefitinib he PROTAC-a-VHL e whakaohooho ana i te paheketanga o nga mutants EGFR me EGFR me te DC50 o 11.7 nM me te 22.3 nM mo te HCC827 pūtau (Exon 19 del) me te pūtau H3255 (L858R). |
| CPDB3615 | Nazartinib; EGF816; NVS-816 | Ko te Nazartinib, e mohiotia ana ko EGF816 me te NVS-816, he aukati-waha, e kore e taea te whakahoki, tuatoru-whakatupuranga, mutant-selectective epidermal growth factor receptor (EGFR) inhibitor, me te mahi antineoplastic pea. |
| CPDB0934 | EAI-045 | Ko te EAI045 he kaikawe EGFR kaha me te whiriwhiri. Ko te EAI045 e whai ana i nga mutants EGFR-aukati tarukino kua tohua engari e tohungia ana te kaikawe momo mohoao. Ko te EAI045 te whakakore i te L858R / T790M-mutant EGFR me te kaha iti-nanomolar i roto i nga whakamatautau koiora. |
| CPDB0101 | Poziotinib | Ko nga hanganga kei roto poziotinib kei te tirotirohia i roto i nga whakamatautau haumanu mo te maimoatanga o te EGFR-mutant lung adenocarcinoma. |
| CPDB0137 | Osimertinib Mesylate | Ko Osimertinib, e mohiotia ana ko mereletinib me te AZD-9291, he kaiwhakapae tuatoru-whakatupuranga EGFR, i whakaatu i te oati i roto i nga rangahau preclinical me te whakarato i te tumanako mo nga turoro me nga mate pukupuku mate pukupuku kua kaha ki te aukati i nga aukati EGFR o naianei. |
