THZ531

Orukọ Kemikali:

(R,E)-N-(4- (3-(5-chloro-4--(1H-indol-3-yl)pyrimidin-2-yl)amino)piperidine-1-carbonyl) phenyl)-4- (dimethylamino) ṣugbọn-2-enamide

KỌỌDỌ SMILES:

"O=C(NC1=CC=C(N2C[C@H](NC3=NC=C(Cl)C(C4=CNC5=C4C=CC=C5)=N3)CCCC2)=O)C= C1)/C=C/CN(C)C"

Koodu InChi:

InChI=1S/C30H32ClN7O2/c1-37(2)15-6-10-27(39)34-21-13-11-20(12-14-21)29(40)38-16-5-7- 22 (19-38) 35-30-33-18-25 (31) 28 (36- 30)24-17-32-26-9-4-3-8-23(24)26/h3-4,6,8-14,17-18,22,32H,5 ,7,15-16,19H2,1-2H3,(H,34,39)(H,33,35,36)/b10-6+/t22-/m1/s1

Bọtini InChi:

RUBYHLPRZRMTJO-MOVYNIQHSA-N

Koko-ọrọ:

THZ-531, THZ 531, THZ531, 1702809-17-3

Solubility:Tiotuka ni DMSO

Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu).

Apejuwe:

THZ531 jẹ CDK12 kovalent ati inhibitor covalent CDK13. Kinases ti o gbẹkẹle cyclin 12 ati 13 (CDK12 ati CDK13) ṣe awọn ipa to ṣe pataki ni ilana ti transcription pupọ. THZ531 ti ko yipada ni idojukọ cysteine ​​kan ti o wa ni ita agbegbe kinase. THZ531 fa isonu ti ikosile jiini pẹlu pipadanu nigbakanna ti elongating ati hyperphosphorylated RNA polymerase II. THZ531 dinku ikosile ti awọn jiini idahun ibaje DNA ati awọn jiini ifosiwewe transcription ti o ni nkan ṣe pataki. THZ531 bosipo fa iku apoptotic sẹẹli. Awọn ohun elo kekere ti o lagbara lati fojusi pataki CDK12 ati CDK13 le ṣe iranlọwọ lati ṣe idanimọ awọn iru-ẹda alakan ti o gbẹkẹle pataki lori awọn iṣẹ kinase wọn.

afojusun: CDK