Riviciclib

Orukọ Kemikali:

2- (2-chlorophenyl) -5,7-dihydroxy-8- ((2R,3S) -2- (hydroxymethyl) -1-methylpyrrolidin-3-yl) -4H-chromen-4-ọkan hydrochloride

KỌỌDỌ SMILES:

O=C1C=C(C2=CC=CC=C2Cl)OC3=C1C(O)=CC(O)=C3[C@H]4[C@H](CO)N(C)CC4.[H] Cl

Koodu InChi:

InChi=1S/C21H20ClNO5.ClH/c1-23-7-6-12(14 (23)10-24)19-15(25)8-16(26)20-17(27)9-18(28-) 21 (19) 20) 11-4-2-3-5-13 (11)22;/h2-5,8-9,12,14,24-26H,6-7,10H2,1H3;1H/t12 -,14+;/m1./s1

Bọtini InChi:

OOVTUOCTLAERQD-OJMBIDBESA-N

Koko-ọrọ:

P276-00; P-276-00; P 276-00; P-27600; P 27600; P 27600; Riviciclib, Riviciclib HCl

Solubility: 

Ibi ipamọ: 

Apejuwe:

Riviciclib, ti a tun mọ ni P276-00, jẹ oludena flavone ati cyclin ti o gbẹkẹle kinase (CDK) pẹlu iṣẹ-ṣiṣe antineoplastic ti o pọju. P276-00 yiyan sopọ si ati ki o ṣe idiwọ Cdk4/cyclin D1, Cdk1/cyclin B ati Cdk9/cyclin T1, serine/threonine kinases ti o ṣe awọn ipa pataki ninu ilana ilana sẹẹli sẹẹli ati afikun cellular. Idinamọ ti awọn kinases wọnyi nyorisi imuni ọmọ inu sẹẹli lakoko iyipada G1/S, nitorinaa yori si ifakalẹ ti apoptosis, ati idinamọ ti ilọsiwaju sẹẹli tumo.

afojusun: CDK