CB-839
Alaye ọja
ọja Tags
| Iwọn Pack | Wiwa | Iye owo (USD) |
| 100mg | O wa | 500 |
| 500mg | O wa | 800 |
| 1g | O wa | 1200 |
| Awọn iwọn diẹ sii | Gba Awọn asọye | Gba Awọn asọye |
Orukọ Kemikali:
2- (pyridin-2-yl) -N- (5- (4---6--2- (3- (trifluoromethoxy) phenyl) acetamido) pyridazin-3-yl) butyl) -1,3,4-thiadiazol -2-yl) acetamide
KỌỌDỌ SMILES:
O=C(NC1=CC=C(CCCC2=NN=NC(NC(CC3=NC=CC=C3)=O)S2)N=N1)CC4=CC(OC(F)(F)F)=CC = C4
Koodu InChi:
InChi=1S/C26H24F3N7O3S/c27-26(28,29)39-20-9-5-6-17(14-20)15-22(37)31-21-12-11-18(33-34- 21)7-1-2-10-24-35-36-25(40-24)32-23(38)16-19-8-3-4-13-30-19/h3-6,8- 9,11-14H,1-2,7,10,15-16H2,(H,31,34,37)(H,32,36,38)
Bọtini InChi:
PRAAPINBUWJLGA-UHFFFAOYSA-N
Koko-ọrọ:
CB-839, CB839, CB 839, 1439399-58-2
Solubility:Tiotuka ni DMSO
Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu).
Apejuwe:
"CB-839 jẹ inhibitor orally bioavailable inhibitor ti glutaminase, pẹlu iṣẹ ṣiṣe antineoplastic ti o pọju. Lori iṣakoso ẹnu, CB-839 yiyan ati aibikita ṣe idiwọ glutaminase, enzymu mitochondrial ti o ṣe pataki fun iyipada ti amino acid glutamine sinu glutamate. Nipa didi glutamine. iṣamulo, isodipupo ni awọn sẹẹli ti o dagba ni iyara ti bajẹ lori iyipada ti glutamine exogenous sinu glutamate ati awọn iṣelọpọ glutamate lati pese agbara ati ṣe agbekalẹ awọn bulọọki ile fun iṣelọpọ ti awọn macromolecules, eyiti o nilo fun idagbasoke cellular ati iwalaaye.
Ifojusi: Glutaminase
