Alvocidib

Alvocidib
  • Orukọ:Alvocidib
  • Katalogi No.CPD100905
  • CAS No.:131740-09-5 (HCl) 146426-40-6 (ipilẹ ọfẹ)
  • Ìwọ̀n Molikula:401.84
  • Fọọmu Kemikali:C21H20ClNO5
  • Fun iwadi ijinle sayensi nikan, kii ṣe fun awọn alaisan.

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    Orukọ Kemikali:

    2- (2-chlorophenyl) -5,7-dihydroxy-8- ((3R,4S) -3-hydroxy-1-methylpiperidin-4-yl) -4H-chromen-4-ọkan

    KỌỌDỌ SMILES:

    O=C1C=C(C2=CC=CC=C2Cl)OC3=C([C@H]4[C@@H](O)CN(C)CC4)C(O)=CC(O)=C13

    Koodu InChi:

    InChi=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(28-21) 19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17 +/m1/s1

    Bọtini InChi:

    BIIVYFLTOXDAOV-PXAZEXFGSA-N

    Koko-ọrọ:

    L 86-8275; L-868275; L 868275; L868275; HMR 1274; HMR-1274; HMR1274; Flavoperidol; Alvocidib

    Solubility: 

    Ibi ipamọ: 

    Apejuwe:

    Alvocidib jẹ agbo N-methylpiperidinyl chlorophenyl flavone sintetiki. Gẹgẹbi oludena ti kinase ti o gbẹkẹle cyclin, alvocidib nfa imudani ọmọ inu sẹẹli nipasẹ idilọwọ phosphorylation ti awọn kinases ti o gbẹkẹle cyclin (CDKs) ati nipasẹ ilana ilana cyclin D1 ati D3 ikosile, ti o mu ki G1 cell cycle arrest ati apoptosis. Aṣoju yii tun jẹ oludena ifigagbaga ti iṣẹ ṣiṣe triphosphate adenosine. Ṣayẹwo fun awọn idanwo ile-iwosan ti nṣiṣe lọwọ tabi awọn idanwo ile-iwosan pipade ni lilo aṣoju yii.

    afojusun: CDK


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