| Ologbo # | Orukọ ọja | Apejuwe |
| CPDB0157 | BI-847325 | BI-847325 jẹ oludena meji MEK/Aurora kinase ti o yan pẹlu awọn iye IC50 ti 3, 25, 15, 25, ati 4 nM fun X. laevis Aurora B, eniyan Aurora A ati Aurora C, ati eniyan MEK1 ati MEK2, lẹsẹsẹ. O le ṣe idiwọ idagbasoke ati iwalaaye ti awọn laini sẹẹli melanoma ti o ni itọju ati oogun, dinku ikosile ti MEK ati Mcl-1 lakoko ti o pọ si ikosile ti amuaradagba pro-apoptotic Bim. Ni 70 mg / kg, BI-847325 nfa apoptosis ni itọju-naive ati oogun-sooro xenografted melanoma ni vivo. |
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