MC180295

Orukọ Kemikali:

Rel- (4-amino-2- ((2S)-bicyclo [2.2.1] heptan-2-yl) amino) thiazol-5-yl) (2-nitrophenyl) methanone

KỌỌDỌ SMILES:

O=C(C1=C(N)N=C(N[C@@H]2C(C3)CCC3C2)S1)C4=CC=CC=C4[N+]([O-])=O

Koodu InChi:

InChi=1S/C17H18N4O3S/c18-16-15(14(22)11-3-1-2-4-13(11)21(23)24)25-17(20-16) )19-12-8-9-5-6-10(12)7-9/h1-4,9-10,12H,5-8,18H2,(H,19,20)/t9?,10? ,12-/m0/s1

Bọtini InChi:

JRNXAQINDCOHGS-CBINBANVSA-N

Koko-ọrọ:

Solubility: 

Ibi ipamọ: 

Apejuwe:

MC180295 jẹ onidalẹkun CDK9 yiyan pupọ (IC50 = 5 nM). (MC180295 ni iṣẹ ṣiṣe egboogi-akàn gbooro ni fitiro ati pe o munadoko ninu awọn awoṣe akàn vivo. Ni afikun, idinamọ CDK9 ṣe ifarabalẹ si inhibitor checkpoint ajẹsara α-PD-1 ni vivo, ti o jẹ ki o jẹ ibi-afẹde ti o dara julọ fun itọju ailera akàn ti akàn.

afojusun: CDK9