Voruciclib

Orukọ Kemikali:

2- (2-Chloro-4- (trifluoromethyl) phenyl) -5,7-dihydroxy-8- ((2R,3S) -2- (hydroxymethyl) -1-methylpyrrolidin-3-yl) -4H-1-benzopyran -4-ọkan

KỌỌDỌ SMILES:

O=C1C=C(C2=CC=C(C(F)(F)F)C=C2Cl)OC3=C([C@H]4[C@H](CO)N(C)CC4)C (O)=CC(O)=C13

Koodu InChi:

InChi=1S/C22H19ClF3NO5/c1-27-5-4-12(14(27)9-28)19-15(29)7-16(30)20-17(31)8-18(32-21(32-21) 19)20)11-3-2-10 (6-13 (11)23)22(24,25)26/h2-3,6-8,12,14,28-30H,4-5,9H2, 1H3 / t12-, 14 + / m1 / s1

Bọtini InChi:

MPGRAKIAJJGMM-OCCSQVGLSA-N

Koko-ọrọ:

P1446A05, P1446A-05, P1446A 05, Voruciclib

Solubility: 

Ibi ipamọ: 

Apejuwe:

Voruciclib, ti a tun mọ ni P1446A-05, jẹ amuaradagba kinase inhibitor kan pato fun kinase ti o gbẹkẹle cyclin 4 (CDK4) pẹlu iṣẹ-ṣiṣe antineoplastic ti o pọju. CDK4 inhibitor P1446A-05 ni pato ṣe idiwọ CDK4-mediated G1-S alakoso iyipada, mimu gigun kẹkẹ sẹẹli ati idilọwọ idagbasoke sẹẹli alakan. Serine / threonine kinase CDK4 ni a ri ni eka kan pẹlu D-type G1 cycins ati ki o jẹ akọkọ kinase lati di mu ṣiṣẹ lori mitogenic fọwọkan, dasile awọn sẹẹli lati ipele quiescent sinu ipele gigun kẹkẹ G1 / S idagbasoke; Awọn eka CDK-cyclin ti han lati phosphorylate awọn retinoblastoma (Rb) ifosiwewe transcription ni kutukutu G1, nipo histone deacetylase (HDAC) ati idilọwọ ifasilẹ transcriptional.

afojusun: CDK4