THZ2

Orukọ Kemikali:

N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]phenyl]-3-[[(E) -4-(dimethylamino)sugbon-2- enoyl]amino]benzamide

KỌỌDỌ SMILES:

O=C(NC1=CC=CC(NC2=NC=C(Cl)C(C3=CNC4=C3C=CC=C4)=N2=C1)C5=CC=CC(NC(/C=C/CN) (C)C)=O)=C5

Koodu InChi:

InChi=1S/C31H28ClN7O2/c1-39(2)15-7-14-28(40)35-21-9-5-8-20(16-21)30(41)36-22-10-6- 11-23 (17-22) 37-31-34-19-26 (32)29 (38-31)25-18-33-27-13-4-3-12-24 (25)27/h3- 14,16-19,33H,15H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b14-7+

Bọtini InChi:

FONRCZUZCHXWBD-VGOFMYFVSA-N

Koko-ọrọ:

THZ-2, THZ 2, THZ2, 1604810-84-5

Solubility:Tiotuka ni DMSO

Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu).

Apejuwe:

THZ2, afọwọṣe ti THZ1, pẹlu agbara lati tọju akàn igbaya igbaya Mẹta-odi (TNBC), o jẹ oludaniloju CDK7 ti o lagbara ati ti o yan eyi ti o bori aiṣedeede ti THZ1 ni vivo. IC50: CDK7 = 13.9 nM; Awọn sẹẹli TNBC = 10 nM

afojusun: CDK