SEL120-34A

Orukọ Kemikali:

7,8-Dibromo-9-methyl-2-piperazin-1-yl-5,6-dihydro-4H-imidazo[4,5,1-ij] quinoline Hydrochloride

KỌỌDỌ SMILES:

CC1=C(Br)C(Br)=C2CCCN3C2=C1N=C3N4CCNCC4.[H]Cl

Koodu InChi:

InChI=1S/C15H18Br2N4.ClH/c1-9-11(16)12(17)10-3-2-6-21-14(10)13(9)19-15(21)20-7-4- 18-5-8-20;/h18H,2-8H2,1H3;1H

Bọtini InChi:

GQXLWUCQESKBSC-UHFFFAOYSA-N

Koko-ọrọ:

SEL120-34A; SEL 120-34A; SEL-120-34A; SEL12034A; SEL 12034A; SEL-12034A

Solubility: 

Ibi ipamọ: 

Apejuwe:

SEL120-34A jẹ oludaniloju CDK8 ti o lagbara ati yiyan ti nṣiṣe lọwọ ninu awọn sẹẹli AML pẹlu awọn ipele giga ti serine phosphorylation ti STAT1 ati awọn ibugbe transactivation STAT5. EL120-34A ṣe idiwọ phosphorylation ti STAT1 S727 ati STAT5 S726 ninu awọn sẹẹli alakan ni fitiro. Ni igbagbogbo, ilana ti STATs- ati NUP98-HOXA9-kikọsilẹ ti o gbẹkẹle ni a ti ṣakiyesi bi ilana iṣe ti o ga julọ ni vivo.

afojusun: CDK8