LDC000067

Orukọ Kemikali:

3-[[6- (2-Methoxyphenyl)-4-pyrimidinyl] amino] benzenemethanesulfonamide

KỌỌDỌ SMILES:

O=S(CC1=CC=CC(NC2=NC=NC(C3=CC=CC=C3OC)=C2)=C1)(N)=O

Koodu InChi:

InChi=1S/C18H18N4O3S/c1-25-17-8-3-2-7-15(17)16-10-18(21-12-20-16)22-14-6 -4-5-13 (9-14)11-26 (19,23)24/h2-10,12H,11H2,1H3,(H2,19,23,24)(H,20,21,22)

Bọtini InChi:

GGQCIOOSELPMBB-UHFFFAOYSA-N

Koko-ọrọ:

LDC000067; LDC-000067; LDC 000067

Solubility: 

Ibi ipamọ: 

Apejuwe:

LDC000067 jẹ oludena CDK9 ti o lagbara ati yiyan. LDC000067 ni idinamọ in vitro transcription ni ATP-idije ati ọna ti o gbẹkẹle iwọn lilo. Isọjade ikosile jiini ti awọn sẹẹli ti a tọju pẹlu LDC000067 ṣe afihan idinku yiyan ti awọn mRNAs igba diẹ, pẹlu awọn olutọsọna pataki ti afikun ati apoptosis. Itupalẹ ti iṣelọpọ de novo RNA daba ipa rere jakejado ti CDK9. Ni ipele molikula ati cellular, LDC000067 awọn ipa ẹda ti o jẹ ihuwasi ti idinamọ CDK9 gẹgẹbi imudara imudara ti RNA polymerase II lori awọn Jiini ati, pataki julọ, ifakalẹ ti apoptosis ninu awọn sẹẹli alakan. LDC000067 ṣe idiwọ P-TEFb-igbẹkẹle in vitro transcription. Ṣe agbejade apoptosis in vitro ati in vivo ni apapo pẹlu BI 894999.

afojusun: CDK9