CP-456773 iṣuu soda

CP-456773 iṣuu soda
  • Orukọ:CP-456773 iṣuu soda
  • Katalogi No.CPDD1600
  • CAS No.:256373-96-3
  • Ìwúwo Molikula:426.4628
  • Fọọmu Kemikali:C20H23N2NaO5S
  • Fun iwadi ijinle sayensi nikan, kii ṣe fun awọn alaisan.

    Alaye ọja

    ọja Tags

    Iwọn Pack Wiwa Iye owo (USD)
    100mg O wa 500
    500mg O wa 800
    1g O wa 1200
    Awọn iwọn diẹ sii Gba Awọn asọye Gba Awọn asọye

    Orukọ Kemikali:

    soda ((1,2,3,5,6,7-hexahydro-s-indacen-4-yl) carbamoyl) ((4- (2-hydroxypropan-2-yl)furan-2-yl) sulfonyl) amide

    KỌỌDỌ SMILES:

    O=S(C1=CC(C(C)(O)C)=CO1)([N-]C(NC2=C3CCCC3=CC4=C2CCC4)=O)=O.[Na+]

    Koodu InChi:

    InChi=1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15 -7-3-5-12 (15) 9-13-6-4-8-16 (13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23 );/q+1/p-1

    Bọtini InChi:

    LFQQNXFKPNZRFT-UHFFFAOYSA-M

    Koko-ọrọ:

    MCC950, MCC 950, MCC-950, CP-45677, CP45677, CP 45677, CRID-3, CRID3, CRID 3, CP-456773 sodium iyọ, Cytokine Tu inhibitory oògùn 3, 256-373-96

    Solubility:Tiotuka ni DMSO

    Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu).

    Apejuwe:

    CP-456773, ti a tun mọ ni MCC950 ati CRID3, jẹ oludaniloju itusilẹ cytokine ti o lagbara ati yiyan ati inhibitor inflammasome NLRP3 fun itọju awọn arun iredodo. CP-456773 ṣe idiwọ ifasilẹ interleukin 1β (IL-1β) ati sisẹ 1 caspase. MCC950 dinamọ canonical ati aiṣiṣẹ NLRP3 ti kii ṣe ilana ni awọn ifọkansi nanomolar. MCC950 ṣe idiwọ imuṣiṣẹ NLRP3 ni pataki ṣugbọn kii ṣe awọn inflammasomes AIM2, NLRC4 tabi NLRP1. MCC950 dinku iṣelọpọ interleukin-1β (IL-1β) ni vivo ati ki o dinku iwuwo ti encephalomyelitis autoimmune esiperimenta (EAE), awoṣe arun ti ọpọ sclerosis. MCC950 jẹ itọju ailera ti o pọju fun awọn iṣọn-ara NLRP3 ti o ni nkan ṣe, pẹlu autoinflammatory ati awọn arun autoimmune, ati ọpa fun iwadi siwaju sii ti NLRP3 inflammasome ni ilera eniyan ati arun.

    Àkọlé: NLRP3


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