BS-181

Orukọ Kemikali:

N5- (6-aminohexyl) -N7-benzyl-3-isopropylpyrazolo [1,5-a] pyrimidine-5,7-diamine hydrochloride

KỌỌDỌ SMILES:

CC(C1=C2N=C(NCCCCCCN)C=C(NCC3=CC=CC=C3)N2N=C1)C.[H]Cl

Koodu InChi:

InChi=1S/C22H32N6.ClH/c1-17(2)19-16-26-28-21(25-15-18-10-6-5-7-11-18)14-20(27-22(27-22) 19)28)24-13-9-4-3-8-12-23;/h5-7,10-11,14,16-17,25H,3-4,8-9,12-13,15 ,23H2,1-2H3,(H,24,27);1H

Bọtini InChi:

NVIJWMOQODWNFN-UHFFFAOYSA-N

Koko-ọrọ:

Solubility: 

Ibi ipamọ: 

Apejuwe:

BS-181 jẹ oludaniloju CDK ti o yan pupọ fun CDK7 pẹlu IC (50) ti 21 nmol/L. Idanwo awọn CDK miiran ati awọn kinases 69 miiran fihan pe BS-181 nikan ni idinamọ CDK2 ni awọn ifọkansi ti o kere ju 1 micromol/L, pẹlu CDK2 ni idinamọ 35-fold kere si agbara (IC(50) 880 nmol/L) ju CDK7. Ninu awọn sẹẹli MCF-7, BS-181 ṣe idiwọ phosphorylation ti awọn sobusitireti CDK7, igbega imudani ọmọ sẹẹli ati apoptosis lati ṣe idiwọ idagba awọn laini sẹẹli alakan, ati ṣafihan awọn ipa antitumor ni vivo.

afojusun: CDK7