BLU-285
Rincian produk
Tag produk
| Ukuran Pek | Kasadiaan | Harga (USD) |
| 1g | Aya sasayogian | 900 |
| 5g | Aya sasayogian | 3600 |
| 10g | Aya sasayogian | 6200 |
| Langkung Ukuran | Meunang Tanda kutip | Meunang Tanda kutip |
Ngaran Kimia:
(S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-métil-1H-pirazol-4-yl)pyrrolo[2,1-f][1,2,4] ]triazin-4-yl) piperazin-1-yl) pirimidin-5-yl) etana-1-amin
Kode SMILES:
CN1N=CC(C2=CN3C(C(N4CCN(C5=NC=C)([C@@](C)(N)C6=CC=C(F)C=C6)C=N5)CC4)=NC= N3)=C2)=C1
Kodeu InChi:
InChI=1S/C26H27FN10/c1-26(28,20-3-5-22(27)6-4-20)21-13-29-25(30-14-21)36-9-7-35( 8-10-36)2 4-23-11-18(16-37(23)33-17-31-24)19-12-32-34(2)15-19/h3-6,11-17H,7-10,28H2, 1-2H3/t26-/m0/s1
Konci InChi:
DWYRIWUZIJHQKQ-SANMLTNESA-N
kecap konci:
BLU-285, BLU 285, BLU285, Avapritinib
Kalarutan:Leyur dina DMSO
Panyimpenan:0 - 4°C kanggo jangka pondok (poé ka minggu), atanapi -20°C kanggo jangka panjang (bulan).
Katerangan:
Avapritinib (BLU-285) parantos nunjukkeun kagiatan in vitro biokimia dina énzim mutant KIT exon 17, KIT D816V (IC50 = 0.27 nM). Aktivitas sélular Avapritinib dina mutan KIT D816 diukur ku autofosforilasi dina garis sél leukemia sél mast manusa HMC1.2, sareng garis sél mastocytoma mouse P815 kalayan IC50 = 4 sareng 22 nM, masing-masing. Dina sél Kasumi-1, dina (8; 21) -garis sél AML positif sareng mutasi KIT exon 17 N822K, Avapritinib potently ngahambat autophosphorylation mutant KIT N822K (IC50 = 40 nM), signalling hilir, ogé proliferasi sélular (IC50 = 75 nM)[1].
Sasaran: KIT
