Revefenacin

Chemical Name:

1-(2-(3-((4-carbamoylpiperidin-1-yl)methyl)-N-methylbenzamido)ethyl)piperidin-4-yl [1,1'-biphenyl] -2-ylcarbamate

SMILES Kodhi:

O=C(OC1CCN(CCN(C)C(C2=CC=C(CN3CCC(C(N)=O)CC3)C=C2)=O)CC1)NC4=CC=CC=C4C5=CC=CC= C5

InChi Code:

InChI=1S/C35H43N5O4/c1-38(34(42)29-13-11-26(12-14-29)25-40-19-15-28(16-20-40)33(36)41) 23-24-39-21-17-30(18-22-39)44-35(43)37-32-10-6-5-9-31(32)27-7-3-2-4- 8-27/h2-14,28,30H,15-25H2,1H3,(H2,36,41)(H,37,43)

InChi Key:

FYDWDCIFZSGNBU-UHFFFAOYSA-N

Keyword:

Revefenacin, TD-4208, GSK-1160724, TD4208, TD 4208, GSK1160724, GSK 1160724, 864750-70-9

Solubility:Soluble muDMSO

Kuchengeta:0 - 4 ° C kwenguva pfupi (mazuva kusvika mavhiki), kana -20 ° C kwenguva refu (mwedzi).

Tsanangudzo:

MuVitro: Iyo Kis ye revefenacin ndeye 0.42, 0.32, 0.18, 0.56, uye 6.7 nM pamunhu M1, M2, M3, M4 uye M5 receptors, zvichiteerana. Muchiyedzo chekushanda, revefenacin inoratidzwa seanopikisa anoshanda ane inhibition constants yakafanana nekusunga Ki's. Revefenacin inhibitswo agonist-induced contraction yeguinea pig isolated tracheal ring gadziriro ine affinity ye0.1 nM, yakafanana neyakayerwa M3 biding Ki[1]. MuVivo:Mumbwa dzinotindivadza, revefenacin, pamwe netiotropium uye glycopyrronium, inogadzira kuvharika kwakasimba kweacetylcholine-induced bronchoconstriction kweanosvika maawa makumi maviri nemana. Mune makonzo anesthetized, inhaled revefenacin inoratidzira dose-inotenderera 24-hour bronchoprotection kurwisa methacholine-induced bronchoconstriction. Iyo inofungidzirwa 24-awa potency ndeye 45.0 µg/mL uye iyo bronchoprotective potencies inochengetwa mushure memazuva 7 eimwe-yezuva dosing[2].

Chinangwa: mAChR