| CPDB0099 | Quizartinib; AC-010220; AC-220 | Quizartinib inhibitor yeFMS-yakabatana tyrosine kinase 3 (FLT3; Kd = 1.6 nM) uye inoratidza kusarudzwa kwepamusoro kweFLT3 painoedzwa pakatarisana nepaneti ye227 yakawedzera kinases. Inodzivisa kupararira kwemutsara we leukemia yemunhu MV4-11, iyo inobata homozygous FLT3-ITD mutation, ine IC50 inokosha ye 0.56 nM.1 Pa 1 mg / kg / zuva, quizartinib yakaratidzwa kuwedzera kurarama mu mouse. modhi yeFLT3-ITD acute myeloid leukemia uye kubvisa mapundu mune FLT3-inotsamira mbeva xenograft modhi pa10 mg/kg. |
