FLT3

CAT # Product Name Tsanangudzo
CPDB0099 Quizartinib; AC-010220; AC-220 Quizartinib inhibitor yeFMS-yakabatana tyrosine kinase 3 (FLT3; Kd = 1.6 nM) uye inoratidza kusarudzwa kwepamusoro kweFLT3 painoedzwa pakatarisana nepaneti ye227 yakawedzera kinases. Inodzivisa kupararira kwemutsara we leukemia yemunhu MV4-11, iyo inobata homozygous FLT3-ITD mutation, ine IC50 inokosha ye 0.56 nM.1 Pa 1 mg / kg / zuva, quizartinib yakaratidzwa kuwedzera kurarama mu mouse. modhi yeFLT3-ITD acute myeloid leukemia uye kubvisa mapundu mune FLT3-inotsamira mbeva xenograft modhi pa10 mg/kg.
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