| CPDB0157 | BI-847325 | BI-847325 is selective dual MEK/Aurora kinase inhibitor ine IC50 values dze3, 25, 15, 25, uye 4 nM for X. laevis Aurora B, human Aurora A uye Aurora C, uye MEK1 yevanhu uye MEK2, zvichiteerana. Inogona kumisa kukura uye kurarama kweaviri-asina kurapa uye anodzivirira zvinodhaka melanoma cell mitsara, ichideredza kutaura kweMEK neMcl-1 uku ichiwedzera kutaura kwepro-apoptotic protein Bim. Pa 70 mg/kg, BI-847325 induces apoptosis mukurapa-naive uye zvinodhaka-resistant xenografted melanoma in vivo. |
