Flibanserin

Chemical Name:

1-(2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazol-2(3H)-one hydrochloride

SMILES Kodhi:

O=C1NC2=CC=CC=C2N1CCN3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3

InChi Code:

InChI=1S/C20H21F3N4O/c21-20(22,23)15-4-3-5-16(14-15)26-11-8-25(9-12) -26)10-13-27-18-7-2-1-6-17(18)24-19(27)28/h1-7,14H,8-13H2,(H,24,28)

InChi Key:

PPRRDFIXUUSXRA-UHFFFAOYSA-N

Keyword:

Flibanserin, 167933-07-5

Solubility:Soluble muDMSO

Kuchengeta:0 - 4 ° C kwenguva pfupi (mazuva kusvika mavhiki), kana -20 ° C kwenguva refu (mwedzi).

Tsanangudzo:

Flibanserin inyanzvi izere ye5-HT1A receptor (Ki = 1 nM) uye, ine hukama hwakaderera, semuvengi we5-HT2A receptor (Ki = 49 nM) uye anopikisa kana kuti asina simba asina simba agonist weD4 receptor ( Ki = 4–24 nM). Pasinei nekubatana kukuru kweflibanserin kune 5-HT1A receptor, uye nekuda kwezvikonzero zvisingazivikanwi, flibanserin inotora 5-HT1A uye 5-HT2A receptors mu vivo ine zvikamu zvakafanana. Flibanserin inewo yakaderera kushamwaridzana kwe5-HT2B receptor (Ki = 89.3 nM) uye 5-HT2C receptor (Ki = 88.3 nM), iyo yose inozvibata seanopikisa. Flibanserin inonyanya kushandisa 5-HT1A receptors mu prefrontal cortex, ichiratidza sarudzo yedunhu, uye yakawanikwa ichiwedzera dopamine uye norepinephrine mazinga uye kuderedza serotonin mazinga mu rat prefrontal cortex, zviito zvakatsunga kupindirana nekushandiswa kwe5-HT1A. mugamuchiri.[12] Sezvo zvakadaro, flibanserin yakatsanangurwa se norepinephrine-dopamine disinhibitor (NDDI). Flibanserin yakabvumidzwa muna Nyamavhuvhu 2015 kurapwa kwevakadzi vasati vasvika kumwedzi vane hypoactive sex chishuwo chirwere (HSDD).

Chinangwa: 5HT