Quizartinib; AC-010220; AC-220

Chemical Name:

N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl ]phenyl}urea

SMILES Kodhi:

O=C(NC1=CC=C(C2=CN3C(SC4=CC(OCCN5CCOCC5)=CC=C34)=N2)C=C1)NC6=NOC(C)(C)C)=C6

InChi Code:

InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22- 18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4- 9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)

InChi Key:

CVWXJKQAOSCOAB-UHFFFAOYSA-N

Keyword:

Quizartinib, AC-010220, AC010220, AC 010220, AC-220, AC220, AC 220, 950769-58-1

Solubility:Soluble muDMSO

Kuchengeta:0 - 4 ° C kwenguva pfupi (mazuva kusvika mavhiki), kana -20 ° C kwenguva refu (mwedzi)

Tsanangudzo:

Quizartinib inhibitor yeFMS-yakabatana tyrosine kinase 3 (FLT3; Kd = 1.6 nM) uye inoratidza kusarudzwa kwepamusoro kweFLT3 painoedzwa pakatarisana nepaneti ye227 yakawedzera kinases. Inodzivisa kupararira kwemutsara we leukemia yemunhu MV4-11, iyo inobata homozygous FLT3-ITD mutation, ine IC50 inokosha ye 0.56 nM.1 Pa 1 mg / kg / zuva, quizartinib yakaratidzwa kuwedzera kurarama mu mouse. modhi yeFLT3-ITD acute myeloid leukemia uye kubvisa mapundu muFLT3-inotsamira mbeva xenograft modhi pa10 mg/kg.

Chinangwa: FLT3