| CAT # | Product Name | Tsanangudzo |
| CPD100573 | PF-05175157 | PF-05175157 inhibitor ine simba uye inosarudza yezvose acetyl-CoA carboxylase isoform ACC1 inowanikwa zvakanyanya muchiropa uye adipose tishu uye isoform ACC2 inotonga mumaskeletal uye mhasuru dzemwoyo, ine IC50 tsika dze27 nM uye 33 nM, zvichiteerana. ACC inhibitors inhibit de novo lipogenesis uye inowedzera β-oxidation ye-long-chain fatty acids ine mukana wekurapa chirwere cheshuga chechipiri, hepatic steatosis, uye kenza. |
| CPD100572 | ND-646 | ND-646 is-an allosteric inhibitor yeACC enzymes ACC1 uye ACC2 inodzivirira ACC subunit dimerization-kudzvinyirira fatty acid synthesis in vitro uye in vivo. Chronic ND-646 kurapwa kwexenograft uye genetically engineered mouse modhi yeNSCLC inhibited bundu kukura. Kana inopihwa semumiriri mumwechete kana musanganiswa neyakajairwa-ye-kutarisira mushonga carboplatin, ND-646 yakanyatso kudzvanya bundu remapapu muKras; Trp53-/- (inozivikanwawo seKRAS p53) uye Kras; Stk11-/- ( inozivikanwawo seKRAS Lkb1) mbeva mhando dzeNSCLC. ND-646 yakanga yawedzera kushanda zvakanaka kana yasanganiswa necarboplatin, chinhu chinowanikwa chemotherapeutic regimens inoshandiswa kurapa NSCLC yevanhu. |
| CPD100571 | CP-640186 | CP-640186 inhibitor ine simba yemammalian ACCs uye inogona kuderedza uremu hwemuviri nekuvandudza insulin senitivity mumhuka dzekuedza. CP-640186 ichangobva kuratidzwa kuva inhibitor ine simba ye isoforms yemammalian ACCs ine IC50 kukosha kwe55 nM. Iyi ndiyo chete yakataurwa ine simba inhibitor yemammalian ACCs. Mumasero tsika pamwe chete nemhando dzemhuka, CP-640186 inogona kuderedza tishu malonyl-CoA mazinga, inhibit fatty acid biosynthesis, uye inokurudzira fatty acid oxidation. Chinonyanya kukosha, CP-640186 inogona kuderedza mafuta emuviri uye uremu hwemuviri, uye kuvandudza insulin senitivity, kusimbisa ACCs sezvinangwa zveantiobesity uye antidiabetes zvinodhaka. |
| CPD1592 | ND-630 | ND-630 inonzi acetyl-CoA carboxylase (ACC) inhibitor; inhibisa munhu ACC1 uye ACC2 ine IC50 tsika dze 2.1 uye 6.1 nM, zvichiteerana. |
