| CAT # | Product Name | Tsanangudzo |
| CPD9470 | Obeticholic-Asidhi | Obeticholic Acid (INT747; 6-ECDCA) ibhuku rinobva kune cholic acid iyo inoshanda seyakasimba uye inosarudza FXR agonist inoratidzira anticholeretic chiitiko mune in vivo rat modhi yecholestasis. Inodzivirira vascular smooth muscle cell kuzvimba uye kutama pamwe nekusimudzira adipocyte kusiyana uye inogadzirisa adipose cell function in vivo. |
| CPD100579 | fexaramine | Fexaramine inonzi agonist yefarnesoid X receptor (FXR), iyo inonzi bile acid-activated nuclear receptor inodzora bile-acid synthesis, conjugation uye kutakura, pamwe chete nelipid metabolism kuburikidza nezviito zvechiropa uye mumatumbo. Fexaramine ine 100-yakakura hukama hweFXR kupfuura masikirwo emasikirwo uye yakatsanangura zvinangwa zvegenomic uye inosunga nzvimbo paFXR. Kana ichipihwa nemuromo kune mbeva, fexaramine yakabudisa zviito zvinosarudzwa kuburikidza neFXR receptors mumatumbo. |
| CPD100577 | Lithocholic acid | Levallorphan, anozivikanwawo selevallorphan tartate (USAN), iopioid modulator yemhuri yemorphinan inoshandiswa seanopioid analgesic uye opioid antagonist/antidote. Inoshanda seanopikisa we-μ-opioid receptor (MOR) uye semugoni we-κ-opioid receptor (KOR), uye semugumisiro, inovhara migumisiro yevamiririri vane simba vane basa guru remukati senge morphine panguva imwe chete vachibudisa analgesia. . Sean agonist yeKOR, levallorphan inogona kuburitsa maitiro epfungwa akanyanya pamadhisi akakwana anosanganisira kufungidzira, kuparadzaniswa, uye mamwe psychotomimetic mhedzisiro, dysphoria, kufunganya, kuvhiringidzika, dzungu, kuvhiringidzika, kupera simba, manzwiro ekudhakwa, uye zvinoshamisa, zvisingawanzo, kana zviroto zvinoshungurudza. . (Kwakabva: https://en.wikipedia.org/wiki/Levallorphan). |
| CPD100575 | Turofexorate-Isopropyl | Turofexorate isopropyl, inozivikanwawo se WAY-362450 uye XL335, inyanzvi ine simba, inosarudza, uye inobata nemuromo yefarnesoid X receptor (FXR) (EC (50) = 4 nM, Eff = 149%), iyo inoderedza kuzvimba kwechiropa. uye fibrosis mumurine muenzaniso weasiri doro steatohepatitis |
| CPD100574 | GW4064 | GW4064是一种farnesoid X receptor (FXR)激动剂，CV1细胞系中EC50為65 nM。浓度达到1 μM时，其他核受体桧有活。 |
| CPD1549 | Tropifexor | Tropifexor inyowani uye ine simba kwazvo agonist yeFXR ine EC50 ye0.2 nM. |
