| CAT # | Product Name | Tsanangudzo |
| CPD100567 | GW501516 | GW501516 is a synthetic PPARδ-specific agonist inoratidza hukama hwepamusoro hwePPARδ (Ki=1.1 nM) ne> 1000 kupeta kusarudza pamusoro pePPARα nePPARγ. |
| CPD100566 | GFT505 | Elafibranor, inozivikanwawo seGFT-505, ine mbiri PPARα/δ agonist. Elafibranoris parizvino iri kudzidzwa kurapwa kwechirwere chemoyo zvinosanganisira chirwere cheshuga, insulin kuramba, dyslipidemia, uye isiri-doro fatty chiropa chirwere (NAFLD). |
| CPD100565 | Babachinina | Bavachinina inyowani yechisikigo pan-PPAR agonist kubva kumuchero wechinyakare Chinese glucose-kudzikisa herb malaytea scurfpea. Inoratidza mabasa akasimba ane PPAR-γ kupfuura ne PPAR-α uye PPAR-β / δ (EC50?=?0.74 μmol / l, 4.00 μmol / l uye 8.07 μmol / l mumasero 293T, maererano). |
| CPD100564 | Troglitazone | Troglitazone, inozivikanwawo seCI991, ine simba PPAR agonist. Troglitazone is antidiabetic uye anti-inflammatory drug, uye inhengo yeboka remishonga ye thiazolidinediones. Yakanyorerwa varwere vane chirwere cheshuga mellitus Type 2 muJapan Troglitazone, seimwe thiazolidinediones (pioglitazone uye rosiglitazone), inoshanda nekuita peroxisome proliferator-activated receptors (PPARs). Troglitazone i ligand kune ese PPARα uye - zvakanyanya kusimba - PPARγ |
| CPD100563 | Glabridin | Glabridin, imwe yeanoshanda phytochemicals mu licorice extract, inosunga uye inogadzirisa ligand binding domain yePPARγ, pamwe chete nehurefu hwakazara receptor. Iyo zvakare GABAA receptor yakanaka modulator inosimudzira fatty acid oxidation nekuvandudza kudzidza uye ndangariro. |
| CPD100561 | Pseudoginsenoside-F11 | Pseudoginsenoside F11, chigadzirwa chemusikirwo chinowanikwa muAmerican ginseng asi kwete muAsia ginseng, inoveli chikamu PPARγ agonist. |
| CPD100560 | Bezafibrate | Bezafibrate inyanzvi yeperoxisome proliferator-activated receptor alpha (PPARalpha) ine antilipidemic chiitiko. Bezafibrate mushonga wefibrate unoshandiswa kurapa hyperlipidemia. Bezafibrate inoderedza triglyceride mazinga, inowedzera yakakwira density lipoprotein cholesterol mazinga, uye inoderedza yakazara uye yakaderera density lipoprotein cholesterol mazinga. Inowanzo kutengeswa seBezalip |
| CPD100559 | GW0742 | GW0742, inozivikanwawo seGW610742 uye GW0742X iPPARδ/β agonist. GW0742 Inoita Early Neuronal Maturation yeCortical Post-Mitotic Neurons. GW0742 inodzivirira hypertension, vascular inflammatory uye oxidative mamiriro, uye endothelial dysfunction mukudya-induced obesity. GW0742 ine zvinodzivirira zvakananga pamwoyo wekurudyi hypertrophy.GW0742 inogona kuwedzera lipid metabolism mumoyo zvose mu vivo uye in vitro. |
| CPD100558 | Pioglitazone | Pioglitazone Hydrochloride musanganiswa wethiazolidinedione unotsanangurwa kugadzira anti-inflammatory uye antiarteriosclerotic mhedzisiro. Pioglitazone inoratidzwa kudzivirira L-NAME-induced coronary kuzvimba uye arteriosclerosis uye kudzvinyirira yakawedzera TNF-α mRNA inogadzirwa ne aspirin-induced gastric mucosal kukuvara. Pioglitazone Hydrochloride inosimudzira PPAR γ |
| CPD100557 | Rosiglitazone | Rosiglitazone ndeye antidiabetic mushonga mukirasi ye thiazolidinedione yemishonga. Inoshanda se insulin sensitizer, nekusunga kune PPAR receptors mumasero emafuta uye kuita kuti masero awedzere kuterera insulin. Rosiglitazone inhengo ye thiazolidinedione kirasi yemishonga. Thiazolidinediones inoshanda se insulin sensitizer. Vanoderedza glucose, mafuta acid, uye insulini yeropa. Ivo vanoshanda nekusunga kune peroxisome proliferator-activated receptors (PPARs). PPARs zvinhu zvekunyora zvinogara munucleus uye zvinove zvichiitwa nema ligands akadai thiazolidinediones. Thiazolidinediones inopinda muchitokisi, inosunga kune nyukireya receptors, uye inoshandura kutaura kwemajini. |
| CPD100556 | GSK0660 | GSK0660 inosarudza PPARδ muvengi. GSK0660 yakarongeka zvakasiyana-siyana zvinyorwa zve 273 mumasero akabatwa neTNFα akaenzaniswa neTNFα chete. Ongororo yenzira yakaratidza kupfumiswa kwecytokine-cytokine receptor kusaina. Kunyanya, GSK0660 inovhara TNFα-induced upregulation yeCCL8, chemokine inobatanidzwa mukutora leukocyte. GSK0660 inovhara maitiro eTNFα pamashoko e-cytokines anobatanidzwa mukutora leukocyte, kusanganisira CCL8, CCL17, uye CXCL10 uye saka inogona kuvhara TNFα-induced retinal leukostasis. |
| CPD100555 | Oroxin-A | Oroxin A, chinhu chinoshanda chakaparadzaniswa kubva kune herb Oroxylum indicum (L.) Kurz, inomutsa PPARγ uye inhibits α-glucosidase, ichiita antioxidant basa. |
| CPD100546 | AZ-6102 | AZ6102 ine simba TNKS1/2 inhibitor ine 100-fold selectivity inopesana nemamwe maenzymes emhuri yePARP uye inoratidza 5 nM Wnt nzira inhibition mumasero eDLD-1. AZ6102 inogona kugadzirwa zvakanaka mukiriniki inopindirana nemutsinga mhinduro pa20 mg/mL, yakaratidza zvakanaka pharmacokinetics mumhando dzepreclinical, uye inoratidza yakaderera Caco2 efflux kudzivirira dzingangove nzira dzekudzivirira bundu. Iyo canonical Wnt nzira inoita basa rakakosha mukukura kwe embryonic, yevakuru tishu homeostasis, uye gomarara. Germline kuchinja kwezvikamu zvakasiyana zveWnt nzira, zvakadai seAxin, APC, uye ?-catenin, zvinogona kutungamirira kuoncogenesis. Inhibition yepoly(ADP-ribose) polymerase (PARP) catalytic domain ye tankyrases (TNKS1 uye TNKS2) inozivikanwa kuvharira iyo Wnt nzira kuburikidza nekuwedzera kugadzikana kweAxin. |
| CPD100545 | KRP297 | KRP297, inozivikanwawo seMK-0767 uye MK-767, ndeye PPAR agonist inogona kurapwa kwerudzi rwechipiri chirwere cheshuga uye dyslipidemia. Kana ichishandiswa kune ob / ob mbeva, KRP-297 (0.3 kusvika 10 mg / kg) yakaderedza plasma glucose uye insulin mazinga uye yakavandudza kusakanganiswa kwe insulini-yakakurudzira 2DG kutora mumusungo wega nenzira inotsamira. Kurapa kweKRP-297 kunobatsira kudzivirira kukura kwechirwere cheshuga syndromes mukuwedzera pakunatsiridza kukanganiswa kweglucose kutakura muskeletal tsandanyama. |
| CPD100543 | Inolitazone | Inolitazone, inozivikanwawo seEfatutazone, CS-7017, uye RS5444, is an orally bioavailable PAPR-gamma inhibitor ine inogona kuita antineoplastic chiitiko. Inolitazone inosunga uye inoita peroxisome proliferation-activated receptor gamma (PPAR-gamma), iyo inogona kukonzera kupinza kwebundu cell kusiyanisa uye apoptosis, pamwe nekuderedzwa kwebundu cell kuwanda. PPAR-gamma inyukireya hormone receptor uye ligand-activated transcription factor inodzora gene kutaura inobatanidzwa mumaserura maitiro sekusiyanisa, apoptosis, cell-cycle control, carcinogenesis, uye kuzvimba. Tarisa uone kushanda kwekiriniki miedzo kana kuvharwa kwekiriniki miedzo uchishandisa mumiririri uyu. (NCI Thesaurus) |
| CPD100541 | GW6471 | GW6471 inopikisa PPAR α (IC50 = 0.24 μ M). GW6471 inosimudzira inosunga hukama hwePPAR α ligand-binding domain kune co-repressor mapuroteni SMRT uye NCoR. |
| CPDD1537 | Lanifibranor | Lanifibranor, inozivikanwawo se IVA-337, inonzi peroxisome proliferator-activated receptors (PPAR) agonist. |
