Bardoxolone methyl

Igoa vaila'au:

(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-methyl 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a, 9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate

SMILES Code:

O=C([C@]1(CC[C@@]2(C)[C@]3(C)CCC4C(C)(C)C(C(C#N)=C[C@]4 (C)C3=C5)=O)CCC(C)(C)C[C@]1([H])[C@@]2([H])C5=O)OC

InChi Code:

InChI=1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15- 23-29(5)16-19(18-33) 25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22 ?,24+,29+,30-,31-,32+/m1/s1

InChi Key:

WPTTVJLTNAWYAO-OROHISIGSA-N

upu autu:

Bardoxolone methyl, RTA-402, RTA 402, RTA402, NSC-713200, TP-155C, Methyl-CDDO, MethylCDDO, Methyl CDDO, CDDO methyl ester, 218600-53-4

Solubility:Solu i le DMSO

Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), po'o le -20°C mo taimi uumi (masina)

Fa'amatalaga:

Ole oleanane triterpenoid CDDO (Item Numera 81035) ole Nrf2 activator e taofia ai le faʻateleina ma faʻaosofia ai le eseesega ma le apoptosis i sela eseese o le kanesa. O le C-28 methyl ester o le CDDO (CDDO methyl ester) e poloka ai le faʻaogaina o le cellular synthesis o le inducible nitric oxide synthase (iNOS) ma le COX-2 inducible i INF-γ-activated mouse macrophages ma le IC50 tau o le 0.11 nM. E fa'aosofia ai le apoptosis, fa'aoso le fa'aeseesega, ma fa'alavelaveina le tali fa'amalama i sela tumo eseese e ala i le fa'asaina o le fa'ailoga IκBα kinase/NF-κB. O le CDDO methyl ester o loʻo i ai le malosi o le antidiabetic, faʻaitiitia le faʻaalia o le cytokine proinflammatory i le gaʻo maualuga o meaʻai-fafaga ituaiga 2 maʻisuka isumu ma le Leprdb / db mice ma faʻaosoina AMP-activated protein kinase ma LKB1 faʻagaoioia i maso ma ate.

Sini: NF-kB