GSK2256098

Igoa vaila'au:

2-((5-chloro-2-((1-isopropyl-3-methyl-1H-pyrazol-5-yl) amino) pyridin-4-yl) amino)-N-methoxybenzamide

SMILES Code:

CC1=NN(C(=C1)NC2=NC=C(C(=C2)NC3=CC=CC=C3C(=O)NOC)Cl)C(C)C

InChi Code:

InChI=1S/C20H23ClN6O2/c1-12(2)27-19(9-13(3)25-27)24-18-10-17(15(21)11-22-18)23-16-8- 6-5-7-14(16)20(28)26-29-4/h5-12H,1-4H3,(H,26,28)(H2,22,23,24)

InChi Key:

BVAHPPKGOOJSPU-UHFFFAOYSA-N

upu autu:

GSK2256098, GSK-2256098, GSK 2256098, GTPL7939, GTPL 7939, GTPL-7939, 1224887-10-8

Solubility:Solu i le DMSO

Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), poo le -20°C mo taimi uumi (masina).

Fa'amatalaga:

GSK2256098, lea e lauiloa foi o le GTPL7939, o se fa'aoga fa'apipi'i fa'apipi'i kinase-1 (FAK) fa'atasi ai ma gaioiga fa'aantiangiogenic ma antineoplastic. FAK inhibitor GSK2256098 faʻalavelave FAK, lea e mafai ona taofia le faʻagaioiina o le faʻaogaina o le tele o auala faʻaliliuina o faailoilo i lalo, e aofia ai le ERK, JNK / MAPK ma le PI3K / Akt, ma faʻafefe ai le femalagaiga o sela tumo, faʻateleina ma le ola, ma le tumo angiogenesis. O le tyrosine kinase FAK e masani lava ona faʻagaoioia e ala i le fusifusia i integrins i le extracellular matrix (ECM) ae e mafai ona faʻatulafonoina ma faʻamalosia i totonu o ituaiga tumo cell eseese.

Sini: FAK