CP-456773 sodium

Igoa vaila'au:

sodium ((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)((4-(2-hydroxypropan-2-yl)furan-2-yl)sulfonyl)amide

SMILES Code:

O=S(C1=CC(C(C)(O)C)=CO1)([N-]C(NC2=C3CCCC3=CC4=C2CCC4)=O)=O.[Na+]

InChi Code:

InChI=1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3- 5-12(15)9-13-6-4-8-16(13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23);/q; +1/p-1

InChi Key:

LFQQNXFKPNZRFT-UHFFFAOYSA-M

upu autu:

MCC950, MCC 950, MCC-950, CP-45677, CP45677, CP 45677, CRID-3, CRID3, CRID 3, CP-456773 sodium salt, Cytokine release inhibitory drug 3, 256373-96-3

Solubility:Solu i le DMSO

Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), poo le -20°C mo taimi uumi (masina).

Fa'amatalaga:

CP-456773, faʻapitoa foi o le MCC950 ma le CRID3, o se faʻamaʻi malosi ma le filifilia o le cytokine release inhibitor ma le NLRP3 inflammasome inhibitor mo togafitiga o faʻamaʻi pipisi. O le CP-456773 e faʻalavelaveina le faʻaogaina o le interleukin 1β (IL-1β) ma le gaioiga caspase 1. MCC950 poloka le fa'agaioiga NLRP3 canonical ma noncanonical i nanomolar concentrations. MCC950 faʻapitoa faʻasaina le faʻagaoioia o le NLRP3 ae le o le AIM2, NLRC4 poʻo le NLRP1 inflammasomes. MCC950 faʻaitiitia le gaosiga o le interleukin-1β (IL-1β) i vivo ma faʻaitiitia ai le ogaoga o le faʻataʻitaʻiga o le autoimmune encephalomyelitis (EAE), o se faʻataʻitaʻiga faʻamaʻi o le tele sclerosis. O le MCC950 o se togafitiga faʻapitoa mo faʻamaʻi e fesoʻotaʻi ma NLRP3, e aofia ai faʻamaʻi faʻamaʻi ma autoimmune, ma se meafaigaluega mo le suʻesuʻeina atili o le NLRP3 inflammasome i le soifua maloloina o tagata ma faʻamaʻi.

Sini: NLRP3