LX-2761

Igoa vaila'au:

N-(1-((2-(Dimethylamino)ethyl)amino)-2-methyl-1-oxopropan-2-yl)-4-(4-(2-methyl-5-((2S,3R,4R), 5S,6R) -3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)-butanamide

SMILES Code:

O=C(NC(C)(C)C(NCCN(C)C)=O)CCCC1=CC=C(CC2=CC([C@H]3[C@H](O)[C@@ H](O)[C@H](O)[C@@H](SC)O3)=CC=C2C)C=C1

InChi Code:

InChI=1S/C32H47N3O6S/c1-20-10-15-23(29-27(38)26(37)28(39)30(41-29)42-6)19-24(20)18-22- 13-11-21(12-14-22)8-7-9-25(36)34-32(2,3)31(40)33-16-17-35(4)5/h10-15, 19,26-30,37-39H,7-9,16-18H2,1-6H3,(H,33,40)(H,34,36)/t26-,27-,28+,29+,30 -/m1/s1

InChi Key:

BNPZTRDIESRGTC-IXYVTWBDSA-N

upu autu:

LX-2761, LX2761, LX 2761, 1610954-97-6

Solubility:Solu i le DMSO

Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), poo le -20°C mo taimi uumi (masina).

Fa'amatalaga:

LX2761 o se fa'apitonu'u SGLT1 fa'apitonu'u e malosi tele i vitro ma fa'atuai ai le fa'aogaina o le kulukose o le intestinal i totonu o le vivo e fa'aleleia ai le pulea o le glycemic. LX2761 ei ai hSGLt1 2.2 nM; hSGLT2 2.7 nM ma F% =<2. LX2761 ose mole malosi malosi, mautu kemikolo, ma fa'amama fa'atapula'aina na maua fa'amaoniga o manatu i le OGTT i togi maualalo. LX2761 na fuafuaina e tumau i totonu o le manava pe a uma ona tuʻuina atu tautala e faʻalavelave ai le SGLT1 i le lotoifale e aunoa ma le afaina o le SGLT1 / 2 masini i le fatugaʻo.

Sini: SGLT1