Nazartinib; EGF816; NVS-816

Igoa vaila'au:

(R,E)-N-(7-chloro-1-(1-(4-(dimethylamino)ae-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)- 2-methylisonicotinamide

SMILES Code:

O=C(NC1=NC2=CC=CC(Cl)=C2N1[C@H]3CN(C(/C=C/CN(C)C)=O)CCCC3)C4=CC=NC(C)= C4

InChi Code:

InChI=1S/C26H31ClN6O2/c1-18-16-19(12-13-28-18)25(35)30-26-29-22-10-6-9-21(27)24(22)33( 26)20-8-4-5-15-32(17-20)23(34)11-7-14-31(2)3/h6-7,9-13,16,20H,4-5, 8,14-15,17H2,1-3H3,(H,29,30,35)/b11-7+/t20-/m1/s1

InChi Key:

IOMMMLWIABWRKL-WUTDNEBXSA-N

upu autu:

Nazartinib ,EGF816, EGF-816, EGF 816, NVS-816, 1508250-71-2

Solubility:Solu i le DMSO

Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), po'o le -20°C mo taimi uumi (masina)

Fa'amatalaga:

Nazartinib, e lauiloa foi o le EGF816 ma le NVS-816, o se mea e mafai ona tuʻu tautala, e le mafai ona toe faʻafoʻisia, lona tolu-tupulaga, mutant-selective epidermal growth factor receptor (EGFR) inhibitor, faʻatasi ai ma gaioiga antineoplastic. O le EGF816 e fusifusia faʻatasi ma faʻalavelaveina le gaioiga o ituaiga mutant o le EGFR, e aofia ai le T790M EGFR mutant, ma puipuia ai le faʻailogaina o le EGFR. E ono fa'aosoina uma ai le oti o le sela ma fa'alavelaveina le tupu a'e o le tuma i sela tumo e fa'aosoina e le EGFR. O le EGF816 e sili ona fa'alavelaveina ituaiga suiga o le EGFR e aofia ai le T790M, o se suiga lona lua na maua, ma e ono maua ai ni fa'amanuiaga fa'afoma'i i tuma ma T790M-mediated resistance pe a fa'atusatusa i isi EGFR tyrosine kinase inhibitors.

Sini: EGFR