| PUSI # | Igoa Oloa | Fa'amatalaga |
| CPD9470 | Obeticholic-Acid | Obeticholic Acid (INT747; 6-ECDCA) o se tala fou e maua mai i le cholic acid lea e galue o se FXR agonist malosi ma filifilia e faʻaalia ai le anticholeretic faʻataʻitaʻiga i vivo rat model of cholestasis. E taofia ai le fulafula o musele lamolemole vascular ma femalagaiga faapea foi ma le faalauiloaina o le eseesega o le adipocyte ma le faatonutonuina o galuega a le adipose cell in vivo. |
| CPD100579 | fexaramine | Fexaramine o se agonist o le farnesoid X receptor (FXR), o se bile acid-activated nuclear receptor e pulea le faʻaogaina o le talo-acid, faʻatasi ma felauaiga, faʻapea foʻi ma le lipid metabolism e ala i gaioiga i le ate ma le inumaga. Fexaramine o loʻo i ai le 100-fold sili atu le vavalalata mo le FXR nai lo mea faʻanatura ma faʻamatalaina le genomic taulaʻi ma nofoaga faʻapipiʻi ile FXR. Pe a tuʻuina tautala ile isumu, ole fexaramine na faia ni gaioiga filifilia e ala ile FXR receptors i totonu ole manava. |
| CPD100577 | Lithocholic-acid | Levallorphan, e lauiloa foi o le levallorphan tartate (USAN), o se opioid modulator o le morphinan aiga o loʻo faʻaaogaina e avea o se opioid analgesic ma opioid antagonist / antidote. E galue o se tagata tetee o le μ-opioid receptor (MOR) ma o se agonist o le κ-opioid receptor (KOR), ma o se taunuuga, e poloka ai aʻafiaga o mea malolosi ma gaioiga sili atu e pei o le morphine aʻo gaosia i le taimi e tasi le analgesia. . I le avea ai o se agonist o le KOR, e mafai e levallorphan ona maua ni faʻafitauli ogaoga o le mafaufau i le lava o tui e aofia ai faʻalavelave, faʻalavelave, ma isi aʻafiaga o le psychotomimetic, dysphoria, popolevale, fenumiai, niniva, faʻalavelave, faʻaleagaina, lagona o le onā, ma miti faʻalavelave, e le masani ai, pe faʻalavelave. . ( Punavai: https://en.wikipedia.org/wiki/Levallorphan). |
| CPD100575 | Turofexorate-Isopropyl | Turofexorate isopropyl, e taʻua foi o le WAY-362450 ma le XL335, o se agonist sili ona malosi, filifilia, ma tautala tautala o le farnesoid X receptor (FXR) (EC (50) = 4 nM, Eff = 149%), lea e faʻaitiitia ai le mumū o le ate. ma fibrosis i murine faʻataʻitaʻiga o steatohepatitis e le o le ava malosi |
| CPD100574 | GW4064 | GW4064是一种farnesoid X receptor (FXR)激动剂，CV1细胞系中EC50为65 nM。浓度达到1 μM时，对其他核受他核受他核受了 |
| CPD1549 | Tropifexor | Tropifexor o se tala ma sili ona malosi agonist o le FXR ma le EC50 o le 0.2 nM. |
