| PUSI # | Igoa Oloa | Fa'amatalaga |
| CPD100464 | Erdafitinib | Erdafitinib, e lauiloa foi o le JNJ-42756493, o se mea e mafai ona tuʻuina atu i le gutu, o le pan fibroblast growth factor receptor (FGFR) inhibitor ma le gaioiga antineoplastic. I luga o le tautala tautala, JNJ-42756493 fusifusia ma faʻalavelave FGFR, lea e mafai ona iʻu ai i le faʻalavelaveina o auala faʻaliliuina faʻailoga e fesoʻotaʻi ma le FGFR ma faʻapea ai le faʻalavelaveina o le faʻateleina o le tumo ma le maliu o le tumo i FGFR-overexpressing sela tumo. FGFR, fa'atulafonoina i le tele o ituaiga sela tumo, o se fa'ato'aga tyrosine kinase e mana'omia mo le fa'atuputeleina o le tumo, fa'avasegaga ma le ola. |
| CPD3618 | TAS-120 | O le TAS-120 o se fa'agata fa'aola e mafai ona tu'u gutu o le fibroblast growth factor receptor (FGFR) fa'atasi ai ma gaioiga antineoplastic. FGFR inhibitor TAS-120 filifili ma irreversibly fusifusia ma taofia FGFR, lea e mafai ona iu i le inhibition o le auala uma e lua FGFR-mediated faailo transduction ala ma tumo cell proliferation, ma faateleina le oti cell i FGFR-overexpressing sela tuma. O le FGFR o se fa'ameamea o le tyrosine kinase e mana'omia mo le fa'atuputeleina o sela tumo, fa'avasegaga ma le ola ma o lona fa'aaliga e fa'atulafonoina i le tele o ituaiga sela tumo. |
| CPDB1093 | Derazantinib; ARQ-087 | Derazantinib, e lauiloa foi o le ARQ-087, o se iniseti e mafai ona tuʻu tautala o le fibroblast growth factor receptor (FGFR) faʻatasi ai ma gaioiga antineoplastic. |
| CPDB0942 | BLU-554 | BLU-554 o le fibroblast growth factor receptor 4 (FGFR4) inhibitor e ono mafai ona togafitia le kanesa o le hepatocellular ma le cholangiocarcinoma. |
| CPD0999 | H3B-6527 | O le H3B-6527 (H3 Biomedicine) o se fa'ato'aga FGFR4 sili ona filifilia ma le malosi o le antitumour i le FGF19 fa'ateleina laina sela ma isumu. |
| CPD0997 | FGF401 | FGF-401 o se inhibitor o FGFR4 maua mai pateni WO2015059668A1, faʻataʻitaʻiga 83; ei ai le IC50 o le 1.9 nM. |
| CPDB0053 | AZD4547 | AZD 4547 o se faʻaiʻuga filifilia o le fibroblast growth factor receptor (FGFR) tyrosine kinase faʻatasi ai ma IC50 tau o 0.2, 2.5, ma 1.8 nM mo FGFR1, 2, ma le 3, faasologa. |
| CPD3610 | BLU-9931 | BLU9931 o se faʻamalosi malosi, filifilia, ma le le mafai ona faʻaaogaina FGFR4 inhibitor ma le IC50 o le 3 nM, e uiga i le 297-, 184-, ma le 50-fold selectivity i luga ole FGFR1 / 2/3, faasologa. |
