| CPDB0157 | BI-847325 | BI-847325 o se filifili lua MEK / Aurora kinase inhibitor ma IC50 tau o 3, 25, 15, 25, ma 4 nM mo X. laevis Aurora B, tagata Aurora A ma Aurora C, ma tagata MEK1 ma MEK2, faasologa. E mafai ona faʻalavelaveina le tuputupu aʻe ma le ola o togafitiga-naive ma vailaʻau-faʻasaʻo laina sela melanoma, faʻaitiitia le faʻaalia o MEK ma Mcl-1 aʻo faʻateleina le faʻaaliga o le pro-apoptotic protein Bim. I le 70 mg/kg, BI-847325 fa'aoso apoptosis i togafitiga-naive ma fualaau faasaina xenografted melanoma i vivo. |
