FLT3

PUSI #	Igoa Oloa	Fa'amatalaga
CPDB0099	Quizartinib; AC-010220; AC-220	O Quizartinib o se faʻalavelave ole FMS-related tyrosine kinase 3 (FLT3; Kd = 1.6 nM) ma faʻaalia le maualuga o le filifilia mo FLT3 pe a faʻataʻitaʻiina i se laulau o 227 kinases faaopoopo. E taofia ai le faʻateleina o le tagata leukemia cell line MV4-11, lea o loʻo i ai se suiga FLT3-ITD homozygous, faʻatasi ai ma le tau IC50 o le 0.56 nM.1 I le 1 mg / kg / aso, quizartinib ua faʻaalia e faʻalautele le ola i se isumu. faʻataʻitaʻiga o le FLT3-ITD acute myeloid leukemia ma faʻaumatia tuma i se faʻataʻitaʻiga xenograft kiore FLT3 faʻalagolago ile 10 mg/kg.