Batefenterol
Fa'amatalaga Oloa
Faailoga o oloa
| Tele o le afifi | Avanoa | Tau (USD) |
| 50mg | E tele | 200 |
| 250mg | E tele | 600 |
| 500mg | E tele | 900 |
| 1g | E tele | 1400 |
| Tele Tele | Maua Upusii | Maua Upusii |
Igoa vaila'au:
"(R)-1-(3-((2-chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl) etil)amino) methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate Batefenterol Succinate"
SMILES Code:
O=C(OC1CCN(CCC(NC2=CC(OC)=C(CNC[C@H](O)C3=CC=C(O)C4=C3C=CC(N4)=O)C=C2Cl)= O)CC1)NC5=CC=CC=C5C6=CC=CC=C6
InChi Code:
InChI=1S/C40H42ClN5O7/c1-52-36-22-33(31(41)21-26(36)23-42-24-35(48)29-11-13-34(47)39-30( 29)12-14-37(49)45-39)43-38(50)17-20-46-18-15-27(16-19-46)53-40(51)44-32-10- 6-5-9-28(32)25-7-3-2-4-8-25/h2-14,21-22,27,35,42,47-48H,15-20,23-24H2, 1H3,(H,43,50)(H,44,51)(H,45,49)/t35-/m0/s1
InChi Key:
URWYQGVSPQJGGB-DHUJRADRSA-N
upu autu:
Batefenterol, TD-5959, GSK961081, 743461-65-6, GSK-961081, GSK 961081, TD5959, TD 5959, 743461-65-6
Solubility:Solu i le DMSO
Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), po'o le -20°C mo taimi uumi (masina)
Fa'amatalaga:
O le Batefenterol o se faʻamaʻi muscarinic ma le β2-adrenergic receptor (β2-AR) agonist (Kis = 1.4, 1.3, ma le 3.7 nM, mo le hM2, hM3, ma le hβ2-AR, faʻasolosolo i totonu o se suʻega faʻamauga radioligand). Batefenterol o loʻo faʻaalia le malosi o le hβ2-AR agonist (EC50 = 0.29 nM) faʻatasi ai ma le 440- ma le 320-fold function selectivity i luga o hβ1- ma hβ3-ARs, faasologa. aano ma taofia le tali atu o le bronchoconstrictor i se su'esu'ega o le bronchoprotection puaa (ED50 = 6.4 µg/mL). O fua fa'atatau o lo'o iai le batefenterol o lo'o i totonu o su'esu'ega fa'afoma'i e togafitia ai fa'ama'i fa'ama'i fa'ama'i fa'ama'i (COPD).
Manulauti: β2-adrenoceptor
