BAY-1895344

Igoa vaila'au:

(R)-3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)morpholine

SMILES Code:

CN1N=CC=C1C2=CC(N3[C@H](C)COCC3)=NC4=C(C5=CC=NN5)N=CC=C24.[H]Cl

InChi Code:

InChI=1S/C20H21N7O.ClH/c1-13-12-28-10-9-27(13)18-11-15(17-5-8-23-26(17)2)14-3-6- 21-2 0(19(14)24-18)16-4-7-22-25-16;/h3-8,11,13H,9-10,12H2,1-2H3,(H,22,25);1H /t13-;/m1./s1

InChi Key:

KWQNBYGUBHMRPY-BTQNPOSSSA-N

upu autu:

1876467-74-1；CAS:1876467-74-1；CAS：1876467-74-1；BAY-1895344, BAY1895344, BAY 1895344

Solubility:Solu i le DMSO

Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), poo le -20°C mo taimi uumi (masina).

Fa'amatalaga:

BAY-1895344 o se ATR filifilia (ataxia-telangiectasia ma Rad3 e fesoʻotaʻi ma le porotini) faʻalavelave e faʻalavelaveina le faʻateleina o le lautele o alaleo o laina sela tumo tagata (median IC50 = 78 nM). BAY-1895344 ua atiaʻe mo le togafitia o tagata mamaʻi e maua i le maualuga o le tuma ma lymphomas, ma o loʻo faʻataʻitaʻiina se vaega I faʻataʻitaʻiga o le saogalemu ma le gafatia mo tagata mamaʻi kanesa.

Sini: ATR