Osimertinib Mesylate

Igoa vaila'au:

N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino )phenyl)acrylamide mesylate

SMILES Code:

CN(CCN(C)C)C1=CC(OC)=C(C=C1NC(C=C)=O)NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2 .OS(=O)(C)=O

InChi Code:

InChI=1S/C28H33N7O2.CH4O3S/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3) 32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24;1-5(2,3)4/ h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32);1H3,(H,2,3,4)

InChi Key:

FUKSNUHSJBTCFJ-UHFFFAOYSA-N

upu autu:

AZD-9291, AZD9291, AZD 9291, Tagrisso, Osimertinib Mesylate, 1421373-66-1

Solubility:Solu i le DMSO

Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), po'o le -20°C mo taimi uumi (masina)

Fa'amatalaga:

Osimertinib, e lauiloa foi o le mereletinib ma le AZD-9291, o le tolu-tupulaga EGFR inhibitors, na faʻaalia le folafolaga i suʻesuʻega faʻapitoa ma maua ai le faʻamoemoe mo tagata mamaʻi e maua i le kanesa o le mama ua sili atu ona teteʻe i le faʻaogaina o le EGFR. AZD9291 e maualuga lona malosi i faʻataʻitaʻiga faʻapitoa ma e faʻafeiloaʻi lelei i faʻataʻitaʻiga manu. E fa'alavelave uma ai le fa'agaoioia ma le fa'asao suiga o le EGFR a'o fa'asaoina le tulaga masani o le EGFR o lo'o i ai i le pa'u masani ma sela o le gut, ma fa'aitiitia ai a'afiaga o lo'o feagai ma vaila'au o lo'o avanoa nei. Osimertinib na fa'amaonia ia Nov. 2015.

Sini: EGFR