Mtengo wa THZ531
Tsatanetsatane wa Zamalonda
Zolemba Zamalonda
| Paketi Kukula | Kupezeka | Mtengo (USD) |
| 100 mg | Zilipo | 500 |
| 500 mg | Zilipo | 800 |
| 1g | Zilipo | 1200 |
| Makulidwe Enanso | Pezani Mawu | Pezani Mawu |
Dzina la Chemical:
(R,E)-N-(4-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)piperidine-1-carbonyl)phenyl)-4- (dimethylamino) koma-2-enamide
SMILES Kodi:
"O=C(NC1=CC=C(C(N2C[C@H](NC3=NC=C(Cl)C(C4=CNC5=C4C=CC=C5)=N3)CCC2)=O)C= C1)/C=C/CN(C)C "
InChi kodi:
InChI=1S/C30H32ClN7O2/c1-37(2)15-6-10-27(39)34-21-13-11-20(12-14-21)29(40)38-16-5-7- 22(19-38)35-30-33-18-25(31)28(36-30)24-17-32-26-9-4-3-8-23(24)26/h3-4, 6,8-14,17-18,22,32H,5,7,15-16,19H2,1-2H3,(H,34,39)(H,33,35,36)/b10-6+/ t22-/m1/s1
InChi Key:
RUBYHLPRZRMTJO-MOVYNIQHSA-N
Mawu ofunika:
THZ-531, THZ 531, THZ531, 1702809-17-3
Kusungunuka:Zosungunuka mu DMSO
Posungira:0 - 4 ° C kwa nthawi yochepa (masiku mpaka masabata), kapena -20 ° C kwa nthawi yaitali (miyezi).
Kufotokozera:
THZ531 ndi covalent CDK12 ndi CDK13 covalent inhibitor. Cyclin-dependent kinases 12 ndi 13 (CDK12 ndi CDK13) amatenga gawo lofunikira pakuwongolera kalembedwe ka jini. THZ531 imalunjika mosasinthika cysteine ili kunja kwa dera la kinase. THZ531 imayambitsa kutayika kwa mafotokozedwe a jini ndi kutayika nthawi imodzi ya elongating ndi hyperphosphorylated RNA polymerase II. THZ531 imachepetsa kwambiri mafotokozedwe a chibadwa cha DNA yowonongeka ndi majini ofunikira kwambiri okhudzana ndi zolembera. THZ531 idapangitsa kufa kwa ma cell a apoptotic. Mamolekyu ang'onoang'ono omwe amatha kulunjika makamaka kwa CDK12 ndi CDK13 atha kuthandizira kuzindikira ma subtypes a khansa omwe amadalira kwambiri zochita zawo za kinase.
Cholinga: CDK
